Building robustness and scalability into the immuno-oncology supply chain

Integrating Business Sustainability into Supply Chain Management

Companies today face the challenge of adopting proper supply chain sustainability (SCS) strategies and practices to respond effectively to emerging global sustainability initiatives. Business sustainability has become a strategic imperative, with a focus on both financial and non-financial sustainability performance, which creates shared value for all stakeholders. This paper examines the integ...

The immuno-oncology framework

Developers of cancer immunotherapy have struggled for decades to achieve clinical success in using the patient's immune system to treat cancer. In the absence of a defined development paradigm for immunotherapies, conventional criteria established for chemotherapy were applied to these agents. This article summarizes the recent lessons for development of agents in the immunotherapy space, descr...

Improving the robustness of a supply chain tactical plan

Increasing Supply Chain Robustness through Process Flexibility and Strategic Inventory

This paper combines process flexibility and strategic inventory to develop an effective disruption mitigation strategy. We consider a manufacturer with multiple plants producing multiple products where strategic inventory can be held for any product. We measure the level of supply chain robustness by proposing the concept of Time-to-Survive (TTS) defined as the maximum time that no customer dem...

Increasing Supply Chain Robustness through Process Flexibility and Inventory

We study a hybrid strategy that uses both process flexibility and inventory to mitigate risks of plant disruption. In this setting, a firm allocates inventory before disruption while facing demand uncertainties; demand is realized after disruption, and the firm schedules its production using process flexibility to minimize lost sales. This interplay between process flexibility and inventory is ...